Fabrication of Matrix Core Tablet as a Bi Phasic Dual-component Delivery System Containing Aceclofenac

نویسنده

  • G VIJAYA
چکیده

The purpose of the present research was to produce a quick/slow biphasic delivery system for aceclofenac. A dual component tablet made of a sustained release tabletted core and an immediate release tabletted coat was prepared by direct compression. Both the core and the coat contained a model drug aceclofenac. The sustained release effect was achieved with polymers hydroxypropyl methylcellulose, ethylcellulose and Xanthan gum to sustain the release of drug. The in-vitro drug release profile from these tablets showed the desired biphasic release behavior of aceclofenac, where the fast releasing component was dissolved within 30 minutes and the drug in the core tablet was released over a period of 12 hours from the matrix tablets. It was observed that Xanthan gum is a better release retarding agent than HPMC and ethyl cellulose as it delayed the release of the drug for more than 15hrs. The results obtained with the dissolution test shows that the release profile is dependent on the type and amount of polymer in the core tablet.

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تاریخ انتشار 2012